I was in a game once where that was implicitly the case due to some game mechanics, and as much as I loved the game that's what killed it for me because I don't live in EST. And I know that other Europeans have the same issue. Everyone setting time aside only works if everyone is roughly in the same timezone and if their schedules roughly match. Aka such a game would necessarily end up being a lot less international.

The second issue is that you know what the main difference between dwrp and p&p is? The number of players. At least as an adult, getting six people together for a session is hard enough. Most DWRPs have significantly more players than that.