It's just like any character in DWRP: if you play well and don't do a bunch of cringey shit like smut-pushing, yapping on plurk about furrsonas and yiff (people seem to be able to get away with sharing furry porn fine so long as they warn for that shit and don't bring it up in unrelated plurks, which is fair imo), or just generally being a creep then you're likely to be well receipted.

I've seen one or two furry/anthro characters (some of them OCs) who have been played in games and seemingly gotten only positive responses, because they're legitimately interesting characters and the players know how to respect boundaries.