The biggest problem with trying to run a game where players can significantly affect things: players always complain they want their characters to be able to change the world but never want to accept any permanent negative consequences for their character's actions. Only the good, never the bad, and players also expect you to completely handhold them and lay out literally every single possible bad outcome, even if those outcomes are only maybes that MIGHT come ingame months down the road; if you're running a plot-heavy game with multiple subplot threads that can also be affected by the characters you sometimes CAN'T know ahead of time how it's all going to ultimately play out.

More than once players played twenty questions with me to blatantly try to metagame and infomod their way past their character suffering any negative repercussions for whatever they were plotting. I've also seen them get massively butthurt and ragequit plots because there was no way for them to magically go right back to playing house with the other half of their kawaii otp as if nothing had ever happened after it was over.

If players want characters to have the power to change the game they need to put on their big girl panties and actually accept the damn consequences to those changes. Your character might get injured, they might die, they might become wanted by local law enforcement, they might lose their house or their money or their powers or their weapons. Shit can happen if you decide to fuck with the powers that be and no you DON'T always know how things will shape up ahead of time.